Deep epistasis in human metabolism
نویسندگان
چکیده
منابع مشابه
Deep epistasis in human metabolism.
We extend and apply a method that we have developed for deriving high-order epistatic relationships in large biochemical networks to a published genome-scale model of human metabolism. In our analysis we compute 33,328 reaction sets whose knockout synergistically disables one or more of 43 important metabolic functions. We also design minimal knockouts that remove flux through fumarase, an enzy...
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ژورنال
عنوان ژورنال: Chaos: An Interdisciplinary Journal of Nonlinear Science
سال: 2010
ISSN: 1054-1500,1089-7682
DOI: 10.1063/1.3456056